Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?

Abstract

We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of ≤ 0.094 μg/ml) and high-level resistance to daptomycin (MIC of ≥ 256 μg/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin.

DOI: 10.1128/AAC.00046-12

Cite this paper

@article{Tran2012NativeVE, title={Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?}, author={Truc Thanh Tran and Siraya Jaijakul and C. Terence Lewis and Lorena D{\'i}az and Diana Panesso and Heidi B. Kaplan and Barbara E. Murray and Audrey R Wanger and C{\'e}sar A. Arias}, journal={Antimicrobial agents and chemotherapy}, year={2012}, volume={56 6}, pages={3461-4} }