Native somatostatin sst2 and sst5 receptors functionally coupled to Gi/o-protein, but not to the serum response element in AtT-20 mouse tumour corticotrophs

@article{Cervia2003NativeSS,
  title={Native somatostatin sst2 and sst5 receptors functionally coupled to Gi/o-protein, but not to the serum response element in AtT-20 mouse tumour corticotrophs},
  author={Davide Cervia and Dominique Fehlmann and Daniel Hoyer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2003},
  volume={367},
  pages={578-587}
}
Of the five cloned somatostatin (SRIF: somatotropin release inhibitory factor) receptors (sst1–5), only sst2 and sst5 receptors appear to be endogenously expressed and functionally active in AtT-20 mouse anterior pituitary tumour cells. In this study, the presence and the functional coupling of SRIF receptors to G-protein in AtT-20 cells was evaluated by receptor autoradiography and guanosine-5'-Ο-(3-[35S]thio)-triphosphate ([35S]GTPγS) binding, respectively. In addition, transcriptional… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

matostatin inhibits potassium - evoked glutamate release by activation of the sst 2 somatostatin receptor in the mouse retina

  • M DalMonte, C Petrucci, A Cozzi, JP Allen, P Bagnoli
  • Naunyn - Schmiedebergs Arch Pharmacol
  • 2003

NVP - SRA 880 , a somatostatin sst 1 receptor antagonist promotes social interactions , reduces aggressive behaviour and stimulates learning

  • D Hoyer, K Dixon, +8 authors P Pfaeffli
  • Pharmacologist
  • 2002

Similar Papers

Loading similar papers…