Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition.

@article{Madina2014NativeMR,
  title={Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition.},
  author={Bhaskara Reddy Madina and V. Seshadri Sravan Kumar and Richard P Metz and Blaine H. M. Mooers and Ralf Bundschuh and Jorge Cruz-Reyes},
  journal={RNA},
  year={2014},
  volume={20 7},
  pages={1142-52}
}
Mitochondrial mRNAs in kinetoplastids require extensive U-insertion/deletion editing that progresses 3'-to-5' in small blocks, each directed by a guide RNA (gRNA), and exhibits substrate and developmental stage-specificity by unsolved mechanisms. Here, we address compositionally related factors, collectively known as the mitochondrial RNA-binding complex 1 (MRB1) or gRNA-binding complex (GRBC), that contain gRNA, have a dynamic protein composition, and transiently associate with several… CONTINUE READING
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