Native chemical ligation of hydrolysis-resistant 3'-peptidyl-tRNA mimics.

Abstract

Hydrolysis-resistant 3'-peptidyl-RNA conjugates that mimic tRNA termini represent a remarkable synthetic challenge, particularly if they contain amino acids with complex side-chain functionalities, such as arginines. Here we demonstrate a novel approach that combines solid-phase synthesis and bioconjugation to obtain these derivatives with high efficiency… (More)
DOI: 10.1021/ja209053b

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@article{Geiermann2011NativeCL, title={Native chemical ligation of hydrolysis-resistant 3'-peptidyl-tRNA mimics.}, author={Anna-Skrollan Geiermann and Norbert Polacek and Ronald Micura}, journal={Journal of the American Chemical Society}, year={2011}, volume={133 47}, pages={19068-71} }