Native and rearranged ALK copy number and rearranged cell count in non-small cell lung cancer: implications for ALK inhibitor therapy.

@article{Camidge2013NativeAR,
  title={Native and rearranged ALK copy number and rearranged cell count in non-small cell lung cancer: implications for ALK inhibitor therapy.},
  author={David Ross Camidge and Margaret C. Skokan and Porntip Kiatsimkul and Barbara Helfrich and Xian Lu and Anna E Baron and Nathan Schulte and Delee A Maxson and Dara L. Aisner and Wilbur A. Franklin and Robert C Doebele and Marileila Varella-Garcia},
  journal={Cancer},
  year={2013},
  volume={119 22},
  pages={3968-75}
}
BACKGROUND Patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) respond to ALK inhibitors. Clinically, the presence of ≥15% cells with rearrangements identified on break-apart fluorescence in situ hybridization (FISH) classifies tumors as positive. Increases in native and rearranged ALK copy number also occur. METHODS In total, 1426 NSCLC clinical specimens (174 ALK-positive specimens and 1252 ALK-negative specimens) and 24 ALK-negative NSCLC cell lines… CONTINUE READING
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