Native Myosin-IXb is a plus-, not a minus-end-directed motor

  title={Native Myosin-IXb is a plus-, not a minus-end-directed motor},
  author={Christopher B. O’Connell and Mark S. Mooseker},
  journal={Nature Cell Biology},
Myosin-IXb (Myo9b) is a single-headed, processive motor that contains a Rho-GTPase-activating protein (GAP) domain within its tail. Although tail-less myosin-IXb motor domain moves towards the minus end of the actin filament, we show here that full-length myosin-IXb is a plus-end-directed motor. This suggests that the tail domain of myosin-IXb regulates motor directionality. 

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