Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135.

@article{Luca2016NativeCR,
  title={Native CB1 receptor affinity, intrinsic activity and accumbens shell dopamine stimulant properties of third generation SPICE/K2 cannabinoids: BB-22, 5F-PB-22, 5F-AKB-48 and STS-135.},
  author={Maria A De Luca and Maria Paola Castelli and Barbara Loi and Alessandra Porcu and Mariella Martorelli and Cristina Miliano and Kathryn Emily Kellett and Colin Davidson and Jacqueline L Stair and Fabrizio Schifano and Gaetano Di Chiara},
  journal={Neuropharmacology},
  year={2016},
  volume={105},
  pages={630-638}
}
In order to investigate the in vivo dopamine (DA) stimulant properties of selected 3rd generation Spice/K2 cannabinoids, BB-22, 5F-PB-22, 5F-AKB-48 and STS-135, their in vitro affinity and agonist potency at native rat and mice CB1 receptors was studied. The compounds bind with high affinity to CB1 receptors in rat cerebral cortex homogenates and stimulate… CONTINUE READING