Nationwide survey in Italy of treatment of Streptococcus pyogenes pharyngitis in children: influence of macrolide resistance on clinical and microbiological outcomes. Artemis-Italy Study Group.

@article{Varaldo1999NationwideSI,
  title={Nationwide survey in Italy of treatment of Streptococcus pyogenes pharyngitis in children: influence of macrolide resistance on clinical and microbiological outcomes. Artemis-Italy Study Group.},
  author={Pietro Emanuele Varaldo and Eugenio A. Debbia and G Nicoletti and D Pavesio and Sandro Ripa and Gian Carlo Schito and Gianna Tempera},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1999},
  volume={29 4},
  pages={869-73}
}
Throat swab specimens were obtained from 3,227 children with symptoms of acute pharyngotonsillitis. After 14 to 21 days, a second throat swab specimen was obtained at a follow-up visit. Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin, azithromycin, and clarithromycin. Eradication rates among the 668 patients who entered the follow-up study were as follows: 84.1%, penicillin recipients; 82.7%, cephalosporin recipients; and 71.7… CONTINUE READING

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Among patients treated with macrolides , the eradication rate was approximately 80% when the infecting organisms were erythromycin - susceptible and approximately 60% when they were erythromycin - resistant .
Among patients treated with macrolides , the eradication rate was approximately 80% when the infecting organisms were erythromycin - susceptible and approximately 60% when they were erythromycin - resistant .
However , at least for a minor self - limiting condition such as acute S. pyogenes pharyngitis , our findings point to a limited overall correlation between in vitro susceptibility ( to penicillins , cephalosporins , or macrolides ) and eradication in patients treated with these drugs and an even weaker correlation between in vitro resistance ( to macrolides ) and noneradication in patients receiving macrolide therapy .
However , at least for a minor self - limiting condition such as acute S. pyogenes pharyngitis , our findings point to a limited overall correlation between in vitro susceptibility ( to penicillins , cephalosporins , or macrolides ) and eradication in patients treated with these drugs and an even weaker correlation between in vitro resistance ( to macrolides ) and noneradication in patients receiving macrolide therapy .
Among patients treated with macrolides , the eradication rate was approximately 80% when the infecting organisms were erythromycin - susceptible and approximately 60% when they were erythromycin - resistant .
Among patients treated with macrolides , the eradication rate was approximately 80% when the infecting organisms were erythromycin - susceptible and approximately 60% when they were erythromycin - resistant .
Among patients treated with macrolides , the eradication rate was approximately 80% when the infecting organisms were erythromycin - susceptible and approximately 60% when they were erythromycin - resistant .
Among patients treated with macrolides , the eradication rate was approximately 80% when the infecting organisms were erythromycin - susceptible and approximately 60% when they were erythromycin - resistant .
Among patients treated with macrolides , the eradication rate was approximately 80% when the infecting organisms were erythromycin - susceptible and approximately 60% when they were erythromycin - resistant .
Among patients treated with macrolides , the eradication rate was approximately 80% when the infecting organisms were erythromycin - susceptible and approximately 60% when they were erythromycin - resistant .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
Nationwide survey in Italy of treatment of Streptococcus pyogenes pharyngitis in children : influence of macrolide resistance on clinical and microbiological outcomes .
Eradication rates among the 668 patients who entered the follow - up study were as follows : 84.1% , penicillin recipients ; 82.7% , cephalosporin recipients ; and 71.7% , macrolide recipients .
However , at least for a minor self - limiting condition such as acute S. pyogenes pharyngitis , our findings point to a limited overall correlation between in vitro susceptibility ( to penicillins , cephalosporins , or macrolides ) and eradication in patients treated with these drugs and an even weaker correlation between in vitro resistance ( to macrolides ) and noneradication in patients receiving macrolide therapy .
However , at least for a minor self - limiting condition such as acute S. pyogenes pharyngitis , our findings point to a limited overall correlation between in vitro susceptibility ( to penicillins , cephalosporins , or macrolides ) and eradication in patients treated with these drugs and an even weaker correlation between in vitro resistance ( to macrolides ) and noneradication in patients receiving macrolide therapy .
Eradication rates among the 668 patients who entered the follow - up study were as follows : 84.1% , penicillin recipients ; 82.7% , cephalosporin recipients ; and 71.7% , macrolide recipients .
Nationwide survey in Italy of treatment of Streptococcus pyogenes pharyngitis in children : influence of macrolide resistance on clinical and microbiological outcomes .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
Over 42% of the 934 strains of Streptococcus pyogenes isolated in the primary study were resistant to erythromycin , azithromycin , and clarithromycin .
However , at least for a minor self - limiting condition such as acute S. pyogenes pharyngitis , our findings point to a limited overall correlation between in vitro susceptibility ( to penicillins , cephalosporins , or macrolides ) and eradication in patients treated with these drugs and an even weaker correlation between in vitro resistance ( to macrolides ) and noneradication in patients receiving macrolide therapy .
However , at least for a minor self - limiting condition such as acute S. pyogenes pharyngitis , our findings point to a limited overall correlation between in vitro susceptibility ( to penicillins , cephalosporins , or macrolides ) and eradication in patients treated with these drugs and an even weaker correlation between in vitro resistance ( to macrolides ) and noneradication in patients receiving macrolide therapy .
However , at least for a minor self - limiting condition such as acute S. pyogenes pharyngitis , our findings point to a limited overall correlation between in vitro susceptibility ( to penicillins , cephalosporins , or macrolides ) and eradication in patients treated with these drugs and an even weaker correlation between in vitro resistance ( to macrolides ) and noneradication in patients receiving macrolide therapy .
However , at least for a minor self - limiting condition such as acute S. pyogenes pharyngitis , our findings point to a limited overall correlation between in vitro susceptibility ( to penicillins , cephalosporins , or macrolides ) and eradication in patients treated with these drugs and an even weaker correlation between in vitro resistance ( to macrolides ) and noneradication in patients receiving macrolide therapy .
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