National trends in long‐term use of prescription opioids

  title={National trends in long‐term use of prescription opioids},
  author={Ramin Mojtabai},
  journal={Pharmacoepidemiology and Drug Safety},
  pages={526 - 534}
  • R. Mojtabai
  • Published 1 May 2018
  • Psychology
  • Pharmacoepidemiology and Drug Safety
This study examined recent trends and correlates of prescription opioid use and long‐term use in the United States. 
Long‐term opioid therapy definitions and predictors: A systematic review
This review sought to (a) describe definitions of long‐term opioid therapy (LTOT) outcome measures, and (b) identify the predictors associated with the transition from short‐term opioid use to LTOT
Changes in consumption of opioid analgesics in Israel 2009 to 2016: An update focusing on oxycodone and fentanyl formulations
The purpose of the study is to assess opioid consumption in Israel during 2009 to 2016 and identify recent trends.
Long‐term opioid treatment and endocrine measures in chronic non‐cancer pain patients: A systematic review and meta‐analysis
There seems to be an impact of L-TOT in CNCP patients on several components of the endocrine system, but the level of evidence is weak.
Decline in Prescription Opioids Attributable to Decreases in Long-Term Use: A Retrospective Study in the Veterans Health Administration 2010–2016
Opioid prescribing trends followed similar trajectories in VHA and non-VHA settings, peaking around 2012 and subsequently declining, however, changes in long-term opioid prescribing accounted for most of the decline in the VHA.
Trends in Prescription Analgesic Use Among Adults With Musculoskeletal Conditions in the United States, 1999-2016
Substantial changes in prescription analgesic use may have occurred as evidence emerged on the cardiovascular risks associated with nonopioid analgesics, and despite recent decreases, opioid use remained more prevalent in 2016 than in 1999.
Prevalence and Childhood Precursors of Opioid Use in the Early Decades of Life
Key Points Question How common is opioid use in the early decades of life, and which childhood risk factors are associated with opioid use in young adulthood? Findings This cohort study assessed
The effects of long‐term opioid treatment on the immune system in chronic non‐cancer pain patients: A systematic review
The effects of L‐TOT on the immune system in CNCP patients and suppression of both the innate and the adaptive immune system has been investigated.
Patterns and predictors of chronic opioid use in older adults: A retrospective cohort study
It is found that chronic opioid use was more prevalent in participants who were more vulnerable (i.e., older age, with multiple comorbidities, and polypharmacy), further studies should evaluate the safety and efficacy of using opioids in this population.
Prescription opioid use among individuals with serious mental illness
Prevalence and Trends of Opioid Use in Patients With Depression in the United States
Beyond the risk for opioid misuse, and opioid use disorder, depression should also be considered when prescribing opioids, and it is therefore important to implement a training to screen for depression in patients receiving opioids for pain management.


Trends in long‐term opioid therapy for chronic non‐cancer pain
To report trends and characteristics of long‐term opioid use for non‐cancer pain for non-cancer pain, a large number of patients with a history of abuse or dependence are surveyed for the first time.
Trends in opioid consumption in the Nordic countries 2002–2006
Long‐term opioid therapy in Denmark: A disappointing journey
This study investigated incidence and predictors for initiating L‐TOT and changes in self‐rated health, pain interference and physical activities in long‐term opioid users.
Changes in opioid and other analgesic use 1995–2010: Repeated cross‐sectional analysis of dispensed prescribing for a large geographical population in Scotland
This work identified and described changes in the pattern of community‐dispensed prescriptions to the Tayside population, Scotland, between 31st March 1995 and31st March 2010.
Trends in long-term opioid prescribing in primary care patients with musculoskeletal conditions: an observational database study
This study has uniquely shown an increase in prescribing long-term opioids to 2009, gradually decreasing from 2011 in the United Kingdom, towards increased prescribing of controlled long-acting opioids and earlier use.
Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis
From 2001 to 2013, concurrent benzodiazepine/opioid use sharply increased in a large sample of privately insured patients in the US and significantly contributed to the overall population risk of opioid overdose.
National trends in the office-based prescription of schedule II opioids.
A substantial increase occurred between 1995 and 2010 in opioid prescriptions in office-based medical visits, especially in visits by middle-aged and older adults and by patients making their first visit to the treating physician, suggesting that physicians have pursued greater pain control despite potential risks of nonmedical use of prescription opioids.
Sedative Prescriptions Are Common at Opioid Initiation: An Observational Study in the Veterans Health Administration
One in five patients newly prescribed opioids also had a sedative prescription, and less than half of patients with concurrent opioid and benzodiazepine prescriptions received these from the same provider.
De Facto Long-term Opioid Therapy for Noncancer Pain
The proposed threshold for long-term opioid therapy provides a checkpoint for physicians to review whether an explicit decision to sustain opioid therapy has been reached, and to ensure that a documented treatment plan and provisions for monitoring medication use and patient outcomes are in place.
Opioid dosing trends and mortality in Washington State workers' compensation, 1996-2002.
Opioid-related deaths in this population may be preventable through use of prudent guidelines regarding opioid use for chronic pain, and it is possible that tolerance or opioid-induced abnormal pain sensitivity may be occurring in some workers who use opioids for chronicPain.