Corpus ID: 15257407

Nasopharyngeal Epithelial Cells Carcinoma Progression and Immortalizes Primary Human Bmi-1 Is a Novel Molecular Marker of Nasopharyngeal

  title={Nasopharyngeal Epithelial Cells Carcinoma Progression and Immortalizes Primary Human Bmi-1 Is a Novel Molecular Marker of Nasopharyngeal},
  author={Li-bing Song and Mu-Sheng Zeng and Wenting Liao and L Zhang and Hao-Yuan Mo and Wan-Li Liu and Jian-Yong Shao and Qiu-liang Wu and Man-Zhi Li and Yun-fei Xia and Li-Wu Fu and Wen-lin Huang and Goberdhan P Dimri and Vimla Band and Yi-Xin Zeng},
The Bmi-1 oncoprotein regulates proliferation and oncogenesis in human cells. Its overexpression leads to senescence bypass in human fibroblasts and immortalization of human mammary epithelial cells. In this study, we report that compared with normal nasopharyngeal epithelial cells (NPEC), Bmi-1 is overexpressed in nasopharyngeal carcinoma cell lines. Importantly, Bmi-1 was also found to be overexpressed in 29 of 75 nasopharyngeal carcinoma tumors (38.7%) by immunohistochemical analysis. In… Expand
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Epstein Barr Virus Volume 2
  • C. Münz
  • Biology
  • Current Topics in Microbiology and Immunology
  • 2015


The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells.
It is reported that Bmi-1, originally identified as a c-Myc cooperating oncoprotein, can bypass senescence, extend the replicative life span, and immortalize MECs and plays a role in the development of human breast cancer. Expand
Immortalization of primary human prostate epithelial cells by c-Myc.
Overall, HPrECs expressing c-Myc retain many characteristics of normal cells, such as the induction of a senescence-like growth arrest in response to oncogenic Ras, an intact p53 response, and an absence of gross karyotypic abnormalities. Expand
The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression
The inverse correlation of bmi-1 and the INK4 locus proteins expression (p16/p14ARF) supports a possible role for bmi -1 misregulation in lung carcinogenesis. Expand
Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes.
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The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.
Results suggested that modulation of Bmi-1 protein might be involved in human colorectal carcinogenesis by repressing the INK4a/ARF proteins. Expand
Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis.
It is proposed that altered expression of BMI-1 and EZH2 is an early event that precedes high rates of proliferation in lung cancer and may contribute to loss of cell identity. Expand
Increased Expression of the EZH 2 Polycomb Group Gene in BMI-1 – Positive Neoplastic Cells during Bronchial Carcinogenesis 1
Polycomb group (PcG) genes are responsible for maintenance of cellular identity and contribute to regulation of the cell cycle. Recent studies have identified several PcG genes as oncogenes, and aExpand
Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer.
Univariate and multivariate analyses showed that a high level of Bmi-1 expression was significantly correlated with axillary lymph node metastases and positive estrogen receptor status, suggesting that Bmi -1 might be involved in the tumor progression and metastasis of invasive ductal breast cancer. Expand
Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma.
High Met protein expression level correlates with poorer survival in late-stage NPC and serves as an independent prognostic indicator; and the Met receptor in NPC is activated by its paracrine ligand HGF from the interstitial tissues rather than by an autocrine loop or its activating mutation. Expand
BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.
The findings suggest that BMI-1 gene alterations in human neoplasms are uncommon, but they may contribute to the pathogenesis in a subset of malignant lymphomas, particularly of mantle cell type. Expand