Nasopharyngeal Biofilm-Producing Otopathogens in Children with Nonsevere Recurrent Acute Otitis Media
@article{Torretta2012NasopharyngealBO,
title={Nasopharyngeal Biofilm-Producing Otopathogens in Children with Nonsevere Recurrent Acute Otitis Media},
author={Sara Torretta and Paola Marchisio and Lorenzo Drago and Elena Baggi and Elena De Vecchi and Werner Garavello and Erica Nazzari and Lorenzo Pignataro and Susanna Esposito},
journal={Otolaryngology–Head and Neck Surgery},
year={2012},
volume={146},
pages={991 - 996}
}Objective. Bacterial biofilms have been detected in biopsies of the adenoid and middle ear mucosa of otitis-prone children and children with chronic middle otitis media. However, the invasiveness of biopsy makes it unsuitable for routine clinical practice, especially in pediatrics. This study aimed to investigate nasopharyngeal biofilm-producing otopathogens (BPOs) of nasopharyngeal swabs (NPS) in children with a history of nonsevere recurrent acute otitis media (RAOM) and healthy controls…
40 Citations
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References
SHOWING 1-10 OF 25 REFERENCES
Differences in nasopharyngeal bacterial flora in children with nonsevere recurrent acute otitis media and chronic otitis media with effusion: implications for management
- Medicine, BiologyThe Pediatric infectious disease journal
- 2003
There are substantial differences in nasopharyngeal flora between children with nonsevere rAOM and children with cOME, and the results should be taken into account to avoid treatment with drugs that are ineffective and likely to select resistant organisms.
Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media.
- MedicineJAMA
- 2006
Direct detection of biofilms on MEM biopsy specimens from children with OME and recurrent OM supports the hypothesis that these chronic middle-ear disorders are biofilm-related.
Diagnostic Accuracy of Nasopharyngeal Swabs in Detecting Biofilm-Producing Bacteria in Chronic Adenoiditis
- MedicineOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- 2011
In comparison with biopsy, nasopharyngeal swabs seem to be inaccurate in detecting biofilm-producing bacteria (BPB) and should be cautiously used in clinical practice.
Morphological evidence of biofilm formation in Greenlanders with chronic suppurative otitis media
- MedicineEuropean Archives of Oto-Rhino-Laryngology
- 2009
This study provides direct morphological evidence of biofilm in samples from human CSOM and may help to explain the microbiological mechanisms of the disease and alter the treatment strategy in the future.
Demonstration of Nasopharyngeal and Middle Ear Mucosal Biofilms in an Animal Model of Acute Otitis Media
- MedicineThe Annals of otology, rhinology, and laryngology
- 2009
The demonstration of mucosal biofilms in both the nasopharynx and middle ear of animals with ME inflammation and/or infection lends further support to the importance of mucosae in the pathogenesis of AOM.
Biofilm Density in the Pediatric Nasopharynx: Recurrent Acute Otitis Media versus Obstructive Sleep Apnea
- MedicineThe Annals of otology, rhinology, and laryngology
- 2009
The resistance of biofilms to antimicrobials, together with their planktonic shedding of organisms, may be an important mechanism in the development of RAOM.
Identification of adenoid biofilms with middle ear pathogens in otitis-prone children utilizing SEM and FISH.
- MedicineInternational journal of pediatric otorhinolaryngology
- 2009
Adenoid Reservoir for Pathogenic Biofilm Bacteria
- Medicine, BiologyJournal of Clinical Microbiology
- 2011
Fluorescence in situ hybridization, lectin binding, and the use of antibodies specific for host epithelial cells demonstrated that pathogens were aggregated, surrounded by a carbohydrate matrix, and localized on and within the epithelial cell surface, which is consistent with criteria for bacterial biofilms.
Micro-ecology of the nasopharyngeal bacterial flora in otitis-prone and non-otitis-prone children.
- Medicine, BiologyActa oto-laryngologica
- 1993
There appears to be an increase in both nontypable Haemophilus influenzae (NTHI) and S. pneumoniae in the nasopharyngeal flora in the otitis-prone child and a decrease in alpha-hemolytic Streptococci in the non-otitis- prone child.
Adherent biofilms in adenotonsillar diseases in children.
- MedicineArchives of otolaryngology--head & neck surgery
- 2008
The presence of biofilms in a significantly higher proportion of patients with chronically inflamed tonsils and adenoids vs patients with obstruction indicates an association between the presence ofBiofilms and chronic inflammation.

