Nasopharyngeal Biofilm-Producing Otopathogens in Children with Nonsevere Recurrent Acute Otitis Media

@article{Torretta2012NasopharyngealBO,
  title={Nasopharyngeal Biofilm-Producing Otopathogens in Children with Nonsevere Recurrent Acute Otitis Media},
  author={Sara Torretta and Paola Marchisio and Lorenzo Drago and Elena Baggi and Elena De Vecchi and Werner Garavello and Erica Nazzari and Lorenzo Pignataro and Susanna Esposito},
  journal={Otolaryngology–Head and Neck Surgery},
  year={2012},
  volume={146},
  pages={991 - 996}
}
Objective. Bacterial biofilms have been detected in biopsies of the adenoid and middle ear mucosa of otitis-prone children and children with chronic middle otitis media. However, the invasiveness of biopsy makes it unsuitable for routine clinical practice, especially in pediatrics. This study aimed to investigate nasopharyngeal biofilm-producing otopathogens (BPOs) of nasopharyngeal swabs (NPS) in children with a history of nonsevere recurrent acute otitis media (RAOM) and healthy controls… 
Nasopharyngeal Microbiota Analysis in Healthy and Otitis-prone Children
TLDR
This study provides a characterization of the URT microbiota in otitis-prone children with and without history of recurrent STMP, suggesting that the role of Dolosigranulum and Corynebacterium in regulating the healthy U RT microbiota should be further studied.
Topographic Distribution of Biofilm-Producing Bacteria in Adenoid Subsites of Children with Chronic or Recurrent Middle Ear Infections
TLDR
The fact that BPBs were significantly more frequently located near the ostium of the ET suggests that the adenoids are a reservoir for bacteria and indicates that hypertrophic adenoiditis with recurrent AOM and/or OME play a role in recurrent Aom and/ or OME.
What are the Most Responsible Pathogenic Bacteria in the Adenoid for Intractable Acute Otitis Media in Japanese Children
TLDR
HI was more frequently isolated from otitis-prone children, and was considered to make AOM more intractable.
Non typable-Haemophilus influenzae biofilm formation and acute otitis media
TLDR
No association of biofilm production and AOM treatment failure or recurrence was found and risk factors of carrying a biofilm-producing strain were established.
Improvement Rate of Acute Otitis Media Caused by Haemophilus influenzae at 1 Week Is Significantly Associated with Time to Recovery
TLDR
An improvement in the severity score after 1 week of treatment may be a useful predictor of the outcome of AOM, and any significant association between relapse or treatment failure and bacterial factors is not identified.
Otitis media and biofilm: An overview
TLDR
This article aims to provide an appraisal of current scientific successes within the field of OM research and clinical management.
Detection of Bacterial Biofilms in Chronic Pharyngitis Resistant to Medical Treatment
TLDR
Determination of BFC using the proposed protocol is feasible, inexpensive, and available and spares the need for sophisticated instruments or approaches.
Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain
TLDR
The number of AOM episodes during the intervention period decreased significantly when compared to that reported during the 6 months period before the probiotic intervention, suggesting L. salivarius PS7 is a promising strain for the prevention of rAOM in infants and children.
Paediatric nasopharyngeal cytology: a new diagnostic opportunity?
TLDR
The need for more structured studies that can test the real effectiveness and usefulness of NPC in defining nasopharyngeal cytological patterns in children with chronic nasopharygeal diseases is suggested by comparing it with established diagnostic techniques.
...
1
2
3
4
...

References

SHOWING 1-10 OF 25 REFERENCES
Differences in nasopharyngeal bacterial flora in children with nonsevere recurrent acute otitis media and chronic otitis media with effusion: implications for management
TLDR
There are substantial differences in nasopharyngeal flora between children with nonsevere rAOM and children with cOME, and the results should be taken into account to avoid treatment with drugs that are ineffective and likely to select resistant organisms.
Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media.
TLDR
Direct detection of biofilms on MEM biopsy specimens from children with OME and recurrent OM supports the hypothesis that these chronic middle-ear disorders are biofilm-related.
Diagnostic Accuracy of Nasopharyngeal Swabs in Detecting Biofilm-Producing Bacteria in Chronic Adenoiditis
TLDR
In comparison with biopsy, nasopharyngeal swabs seem to be inaccurate in detecting biofilm-producing bacteria (BPB) and should be cautiously used in clinical practice.
Morphological evidence of biofilm formation in Greenlanders with chronic suppurative otitis media
TLDR
This study provides direct morphological evidence of biofilm in samples from human CSOM and may help to explain the microbiological mechanisms of the disease and alter the treatment strategy in the future.
Demonstration of Nasopharyngeal and Middle Ear Mucosal Biofilms in an Animal Model of Acute Otitis Media
TLDR
The demonstration of mucosal biofilms in both the nasopharynx and middle ear of animals with ME inflammation and/or infection lends further support to the importance of mucosae in the pathogenesis of AOM.
Biofilm Density in the Pediatric Nasopharynx: Recurrent Acute Otitis Media versus Obstructive Sleep Apnea
TLDR
The resistance of biofilms to antimicrobials, together with their planktonic shedding of organisms, may be an important mechanism in the development of RAOM.
Identification of adenoid biofilms with middle ear pathogens in otitis-prone children utilizing SEM and FISH.
Adenoid Reservoir for Pathogenic Biofilm Bacteria
TLDR
Fluorescence in situ hybridization, lectin binding, and the use of antibodies specific for host epithelial cells demonstrated that pathogens were aggregated, surrounded by a carbohydrate matrix, and localized on and within the epithelial cell surface, which is consistent with criteria for bacterial biofilms.
Micro-ecology of the nasopharyngeal bacterial flora in otitis-prone and non-otitis-prone children.
TLDR
There appears to be an increase in both nontypable Haemophilus influenzae (NTHI) and S. pneumoniae in the nasopharyngeal flora in the otitis-prone child and a decrease in alpha-hemolytic Streptococci in the non-otitis- prone child.
Adherent biofilms in adenotonsillar diseases in children.
TLDR
The presence of biofilms in a significantly higher proportion of patients with chronically inflamed tonsils and adenoids vs patients with obstruction indicates an association between the presence ofBiofilms and chronic inflammation.
...
1
2
3
...