Nascent-peptide-mediated ribosome stalling at a stop codon induces mRNA cleavage resulting in nonstop mRNA that is recognized by tmRNA.

@article{Sunohara2004NascentpeptidemediatedRS,
  title={Nascent-peptide-mediated ribosome stalling at a stop codon induces mRNA cleavage resulting in nonstop mRNA that is recognized by tmRNA.},
  author={Takafumi Sunohara and Kaoru Jojima and Yasufumi Yamamoto and Toshifumu Inada and Hiroji Aiba Aiba},
  journal={RNA},
  year={2004},
  volume={10 3},
  pages={378-86}
}
Recent studies have established that tmRNA-mediated protein tagging occurs at stop codons depending on the C-terminal amino acid sequence of the nascent polypeptide immediately adjacent to those codons. We investigate here how the trans-translation at a stop codon occurs by using model crp genes encoding variants of cAMP receptor protein (CRP). We demonstrate that a truncated crp mRNA is efficiently produced along with a normal transcript from the model gene where tmRNA-mediated protein tagging… CONTINUE READING

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