Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus

@article{Frey2020NascentTR,
  title={Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus},
  author={Tiffany R. Frey and Jozan Brathwaite and Xiaofan Li and Sandeepta Burgula and Ibukun A. Akinyemi and Saurabh Agarwal and Eric M Burton and Mats Ljungman and Michael T. McIntosh and Sumita Bhaduri-McIntosh},
  journal={Journal of Virology},
  year={2020},
  volume={94}
}
Transition from latency to the lytic phase is necessary for herpesvirus-mediated pathology as well as viral spread and persistence in the population at large. Yet, viral genomes in only some cells in a population of latently infected cells respond to lytic triggers, resulting in subpopulations of responsive/lytic and refractory cells. Our investigations into this partially permissive phenotype of the herpesvirus Epstein-Barr virus (EBV) indicate that upon exposure to lytic triggers, certain… 
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