Nascent RNA interaction keeps PRC2 activity poised and in check.

  title={Nascent RNA interaction keeps PRC2 activity poised and in check.},
  author={Syuzo Kaneko and Jinsook Son and Roberto Bonasio and Steven R. S. Shen and Danny F Reinberg},
  journal={Genes & development},
  volume={28 18},
Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of chromatin domains repressive to transcription through catalysis of methylation of histone H3 at Lys27 (H3K27me2/3). However, through its EZH2 subunit, PRC2 also binds to nascent transcripts from active genes that are devoid of H3K27me2/3 in embryonic stem cells. Here, biochemical analyses indicated that RNA interaction inhibits SET domain-containing proteins, such as PRC2, nonspecifically in vitro. However… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 46 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

Similar Papers

Loading similar papers…