Nascent RNA interaction keeps PRC2 activity poised and in check.

@article{Kaneko2014NascentRI,
  title={Nascent RNA interaction keeps PRC2 activity poised and in check.},
  author={Syuzo Kaneko and Jinsook Son and Roberto Bonasio and Steven R. S. Shen and Danny F Reinberg},
  journal={Genes & development},
  year={2014},
  volume={28 18},
  pages={1983-8}
}
Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of chromatin domains repressive to transcription through catalysis of methylation of histone H3 at Lys27 (H3K27me2/3). However, through its EZH2 subunit, PRC2 also binds to nascent transcripts from active genes that are devoid of H3K27me2/3 in embryonic stem cells. Here, biochemical analyses indicated that RNA interaction inhibits SET domain-containing proteins, such as PRC2, nonspecifically in vitro. However… CONTINUE READING
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