Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure.

@article{Dorman2004NasalTO,
  title={Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure.},
  author={David Dorman and Brian E McManus and Carl U. Parkinson and Chris A Manuel and Anna M McElveen and Jeffrey I Everitt},
  journal={Inhalation toxicology},
  year={2004},
  volume={16 6-7},
  pages={481-8}
}
Growing evidence suggests that nasal deposition and transport along the olfactory nerve represents a route by which inhaled manganese and certain other metals are delivered to the rodent brain. The toxicological significance of olfactory transport of manganese remains poorly defined. In rats, repeated intranasal instillation of manganese chloride results in injury to the olfactory epithelium and neurotoxicity as evidenced by increased glial fibrillary acidic protein (GFAP) concentrations in… CONTINUE READING

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