Nasal toxicity of benzalkonium chloride.

  title={Nasal toxicity of benzalkonium chloride.},
  author={Herbert Riechelmann and Tom Deutschle and Anja Stuhlmiller and Silke Gronau and Harald B{\"u}rner},
  journal={American journal of rhinology},
  volume={18 5},
BACKGROUND Benzalkonium chloride (BAC) is added to nasal preparations to prevent microbial contamination. Adverse effects of BAC on human nasal mucosa should be evaluated. METHODS The ciliotoxicity of BAC was assessed in isolated human nasal epithelia from 15 donors. The effects of nasal BAC 0.05% (4 x 200 microL/day for 8 days) on nasal saccharin transport time, inflammatory cells and cytokine levels in nasal secretions, and nasal symptom scores were assessed in a randomized, double-blind… CONTINUE READING


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