Nasal potential difference: a clinical diagnostic test for cystic fibrosis.

  title={Nasal potential difference: a clinical diagnostic test for cystic fibrosis.},
  author={Eric Alton and David. Currie and R B Logan-Sinclair and John O. Warner and Margaret E. Hodson and Duncan M. Geddes},
  journal={The European respiratory journal},
  volume={3 8},
Patients with cystic fibrosis (CF) demonstrate a markedly more negative potential difference (PD) across respiratory epithelia than normal or "diseased" controls. A technique is described for the measurement of nasal PD in both children and adults. 145 non-CF subjects showed a mean PD of -19.0 mV (range -2 to -36) in comparison to 60 patients with cystic fibrosis with mean of -46.0 mV (range -32 to -77). Amongst the latter group those with more severe disease had a more negative PD. Measurement… CONTINUE READING

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Identification of the CF gene: cloning and characterisation of the complimentary DNA

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Identification of the cystic fibrosis gene : genetic analysis

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