Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine

  title={Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine},
  author={Karin E. Fattinger and Neal L. Benowitz and R. T. Jones and Davide Verotta},
  journal={European Journal of Clinical Pharmacology},
AbstractObjective: Several xenobiotics, including cocaine, are dosed by the nasal route for systemic effects. The aim of this study was to estimate and compare cocaine input into the systemic circulation after oral and nasal dosing, and to determine the relevance of local absorption through the nasal mucosa. Methods: Cocaine was administered to healthy volunteers through the intravenous, oral, and nasal routes. Cocaine serum concentrations were measured at frequent intervals. From these data… 
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