Nasal immunization of mice with virus-like particles protects offspring against rotavirus diarrhea.

@article{Coste2000NasalIO,
  title={Nasal immunization of mice with virus-like particles protects offspring against rotavirus diarrhea.},
  author={Alix Therese Coste and Jean Claude Sirard and Kari B Johansen and Jean Pierre Quadrat. Guy Cohen and J. P. Kraehenbuhl},
  journal={Journal of virology},
  year={2000},
  volume={74 19},
  pages={
          8966-71
        }
}
Rotavirus is the major cause of diarrhea among young infants in both humans and animals. Immune protection of newborns by vaccination is difficult to achieve since there is not enough time to mount an immune response before exposure to the virus. We have designed a vaccination strategy mediating transfer of neutralizing antibodies from the mother to the offspring during pregnancy and/or lactation. Adult female mice were nasally immunized with virus-like particles (VLPs) made of viral proteins… CONTINUE READING
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