Nasal delivery of fentanyl

  title={Nasal delivery of fentanyl},
  author={Peter James Watts and Alan M. Smith and Michael A. Perelman},
  journal={Drug Delivery and Translational Research},
Fentanyl, a potent opioid analgesic, is rapidly and efficiently absorbed from the nasal cavity, giving significant potential for nasally administered fentanyl to be used in pain management. Many reported clinical studies have used nasally administered IV solution, often as drops, which requires high volumes of solution to deliver an effective dose, resulting in insignificant runoff and drip which, in turn, compromises absorption and efficacy. More recently, products have been developed and… 
Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers
Pharmacokinetic parameters and bioavailability of the investigated intranasal fentanyl indicated suitability for its intended use as an intranAsal PCA option.
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Various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites are discussed.
The prevalence of nasal obstruction as a consideration in the treatment of opioid overdose.
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In this pilot study, the preadministration of intranasal fentanyl prior to activity in palliative, end-stage hospitalized heart failure patients, safely reduced tachypnea, and the feeling of shortness of breath.
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It is difficult to evaluate the relative efficacies of these treatments on the basis of the available trials, as there are no head-to-head trials comparing any of the newer transmucosal formulations of fentanyl with each other, and the value of any potential meta-analyses including these trials would likely be limited.
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Preliminary data indicate that transdermal fentanyl may be useful in the management of chronic nonmalignant pain, and some patients whose pain was previously uncontrolled became completely pain free.
Fentanyl Pectin Nasal Spray
During long-term treatment of BTPc episodes, fentanyl pectin nasal spray consistently provided effective pain relief in an open-label, 16-week trial and most patients were satisfied or very satisfied with the ease of use and convenience of the nasal spray.
A new formulation of nasal fentanyl spray for postoperative analgesia: a pilot study
It is concluded that these formulations of fentanyl, delivered as nasal spray, have potential clinical utility and patient acceptability and should be considered for clinical utility studies.
Absorption and bioavailability of oral transmucosal fentanyl citrate.
Oral transmucosal fentanyl citrate is a novel, noninvasive dosage form of fentanyl used to provide children and adults with sedation, anxiolysis, and analgesia and bioavailability was greater after OTFC administration than after the oral solution.
A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial
In this open-label, randomised, crossover trial, significantly more patients attained faster ‘meaningful’ pain relief with INFS than OTFC, and more patients preferred INFS to OTFC.
Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives
  • L. Mather
  • Medicine, Biology
    Clinical pharmacokinetics
  • 1983
Fentanyl is rightly regarded as having a redistribution-limited duration of action after single or infrequent doses (analogous to thiopentone), but the magnitude of the pharmacokinetic constants reported for fentanyl are remarkably inconsistent even in healthy volunteers.
Pharmacokinetics and relative bioavailability of fentanyl pectin nasal spray 100 - 800 µg in healthy volunteers.
It is concluded that the pharmacokinetic profile of FPNS suggests this product is suitable for clinical investigation in breakthrough pain in cancer patients and is well tolerated.