Nasal clearance in health and disease.

  title={Nasal clearance in health and disease.},
  author={Lisbeth Illum},
  journal={Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine},
  volume={19 1},
  • Lisbeth Illum
  • Published 2006 in
    Journal of aerosol medicine : the official…
This paper reviews the anatomical and physiological factors of importance for nasal drug delivery and discusses in particular the influence of the nasal mucociliary clearance mechanism on the nasal absorption of drugs. The effect of nasal pathological conditions on the mucociliary clearance mechanism and the possible effect of such disease states on nasal drug transport are also discussed. Strategies for the exploitation of bioadhesive drug delivery systems and especially nasal absorption… CONTINUE READING

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