Nasal bone assessment in fetuses with trisomy 21 at 16–24 weeks of gestation by three‐dimensional ultrasound

@article{Persico2012NasalBA,
  title={Nasal bone assessment in fetuses with trisomy 21 at 16–24 weeks of gestation by three‐dimensional ultrasound},
  author={Nicola Persico and Francisca Sonia Molina and Guillermo Azumendi and Luigi Fedele and Kypros H. Nicolaides},
  journal={Prenatal Diagnosis},
  year={2012},
  volume={32}
}
OBJECTIVE This study aims to investigate the length and shape of the nasal bones in fetuses with trisomy 21 at 16-24 weeks' gestation. [...] Key MethodMETHOD We acquired three-dimensional volumes of the fetal profile from 41 fetuses with trisomy 21. The multiplanar mode was used to measure nasal bone length in the exact midsagittal plane and in parasagittal and oblique views of the fetal face and to examine the nasal bones in the coronal plane. Expand
View on Wiley
fetalmedicine.com
18 Citations
Highly Influential Citations
1
Background Citations
5
Methods Citations
1
Results Citations
2

18 Citations

Citation Type

Citation Type

Sphenofrontal distance on three‐dimensional ultrasound in euploid and trisomy‐21 fetuses at 16–24 weeks' gestation
  • G. Cossellu, N. Persico, +6 authors K. Nicolaides
  • Medicine
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2016
TLDR
To compare the distance between the sphenoid and frontal bones on three‐dimensional ultrasound in euploid and trisomy‐21 fetuses at 16–24 weeks' gestation, 3D ultrasound is used for the first time.
Nasal bone length: prenasal thickness ratio: a strong 2D ultrasound marker for Down syndrome
To evaluate the feasibility of incorporating two‐dimensional ultrasound measurements of nasal bone length (NBL) and prenasal thickness (PT) into the second‐trimester anomaly scan and to determine…
Assessment of the Nasal Bone by 2‐Dimensional Ultrasound in 2 Different Planes: Do They Give the Same Results?
  • S. Kavak, E. Kavak
  • Medicine
    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • 2019
TLDR
This study aimed to compare nasal bone length measurements taken in 2 different planes and to determine whether there is consistency between the measurements.
Spheno‐frontal distance in euploid and trisomy 21 fetuses at 16–24 weeks’ gestation by three‐dimensional ultrasound
TLDR
A reduction in the growth of the anterior cranial base contributes to the mid-facial hypoplasia observed in fetuses with trisomy 21 and euploid fetuses at 16-24 weeks’ gestation by three-dimensional ultrasound.
Is 3D technique superior to 2D in Down syndrome screening? Evaluation of six second and third trimester fetal profile markers
TLDR
3D multiplanar correction prior to the measurement of Down syndrome facial markers is superior to subjective judgment of a correct midsagittal plane by 2D technique in second trimester ultrasound investigations.
Fetal nasal bone length in the second trimester: comparison between population groups from different ethnic origins
TLDR
Comparison of normal ranges of ultrasonographically measured fetal nasal bone length in the second trimester between different ethnic groups shows that distinct ethnic nomograms should be used in a given population rather than an international model.
Predictive role of prenasal thickness and nasal bone for Down syndrome in the second trimester.
TLDR
PNT is increased in fetuses with DS as compared to normal fetuses and PNT/NB≥0.76 in the second trimester is a better predictor of DS than the use of PNT or NB alone.
Fetal diagnostic indications for second and third trimester outpatient pregnancy termination
To determine the frequency of diagnostic indications among women seeking to terminate pregnancies for reasons of fetal abnormality, spontaneous fetal demise, or a genetic disorder in a private…
Three-dimensional versus two-dimensional ultrasound for fetal nasal bone evaluation in the second trimester
  • P. Papasozomenou, A. Athanasiadis, +4 authors B. Tarlatzis
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2015
TLDR
Fetal nasal bone length measured with two-dimensional ultrasound does not differ significantly from three-dimensional measurements, however, three- dimensional ultrasound is superior in detecting unilateral nasal bone hypoplasia or absence and in assessing fetal nasal bone shape.
Is 3D technique superior to 2D in Down syndrome screening? Evaluation of six second and third trimester fetal profile markers
Objective To investigate whether in the clinical setting of second trimester ultrasound (US) investigations 3D multiplanar correction prior to the measurement of Down syndrome (DS) facial markers…
...
1
2
...

References

SHOWING 1-10 OF 14 REFERENCES
Nasal‐bone length in euploid fetuses at 16–24 weeks' gestation by three‐dimensional ultrasound
To establish a normal range of nasal‐bone length at 16–24 weeks' gestation by the use of three‐dimensional (3D) ultrasound and to investigate the effect of deviations from the exact mid‐sagittal…
Prenasal thickness in trisomy‐21 fetuses at 16–24 weeks of gestation
TLDR
To construct a reference range for fetal prenasal thickness between 16 and 24 weeks of gestation and to evaluate the thickness in fetuses with trisomy 21, a total of 21 fetuses were studied.
Assessment of the gap between the fetal nasal bones at 11 to 13 + 6 weeks of gestation by three‐dimensional ultrasound
To detect the presence of a gap between the fetal nasal bones at 11 to 13 + 6 weeks of gestation and to verify if this gap could lead to the erroneous diagnosis of absent nasal bone.
Nasal bone assessment in prenatal screening for trisomy 21.
TLDR
The potential value of assessment of the fetal nasal bone in screening for trisomy 21 is discussed and the evidence based on radiologic, histomorphologic, and sonographic studies shows that nasal bone abnormalities are significantly more common than in euploid fetuses.
Two‐ and three‐dimensional sonographic assessment of the fetal face. 1. A systematic analysis of the normal face
  • D. Rotten, J. Levaillant
  • Medicine
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2004
To detail fetal facial examination in utero using ultrasound, to distinguish between requirements for routine screening and those for precise analysis of fetal facial features, and to assess the use…
Absent or Shortened Nasal Bone Length and the Detection of Down Syndrome in Second-Trimester Fetuses
TLDR
Nasal bone length expressed as MoM seems to be an useful ultrasound marker for Down syndrome in second-trimester fetuses with a high sensitivity and a low false-positive rate.
Three‐dimensional ultrasound with maximal mode rendering: a novel technique for the diagnosis of bilateral or unilateral absence or hypoplasia of nasal bones in second‐trimester screening for Down syndrome
  • B. Benoit, R. Chaoui
  • Medicine
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2005
TLDR
The aim of this study was to analyze the feasibility of assessing nasal bones spatially on prenatal ultrasound in second‐ and third‐trimester fetuses with present and absent nasal bones.
The prenatal development of the human nasal and vomeral bones.
TLDR
Normal prenatal development standards for the nasal and vomeral bones are established, both formed by intramembranous ossification in the membrane covering the cartilaginous nasal capsule, based upon a combination of macroscopic and microscopic analyses on normal human fetuses from spontaneous and induced abortions.
Absence of nasal bone in fetuses with trisomy 21 at 11–14 weeks of gestation: an observational study
TLDR
In screening for trisomy 21, it is estimated that inclusion of examination of the fetal profile for the presence or absence of nasal bone could increase the sensitivity to 85% and decrease the false-positive rate to about 1%.
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
TLDR
An alternative approach, based on graphical techniques and simple calculations, is described, together with the relation between this analysis and the assessment of repeatability.
...
1
2
...