Nasal bone assessment in fetuses with trisomy 21 at 16–24 weeks of gestation by three‐dimensional ultrasound

@article{Persico2012NasalBA,
  title={Nasal bone assessment in fetuses with trisomy 21 at 16–24 weeks of gestation by three‐dimensional ultrasound},
  author={Nicola Persico and Francisca Sonia Molina and Guillermo Azumendi and Luigi Fedele and Kypros H. Nicolaides},
  journal={Prenatal Diagnosis},
  year={2012},
  volume={32}
}
OBJECTIVE This study aims to investigate the length and shape of the nasal bones in fetuses with trisomy 21 at 16-24 weeks' gestation. [...] Key MethodMETHOD We acquired three-dimensional volumes of the fetal profile from 41 fetuses with trisomy 21. The multiplanar mode was used to measure nasal bone length in the exact midsagittal plane and in parasagittal and oblique views of the fetal face and to examine the nasal bones in the coronal plane. Expand
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References

SHOWING 1-10 OF 14 REFERENCES
Nasal‐bone length in euploid fetuses at 16–24 weeks' gestation by three‐dimensional ultrasound
To establish a normal range of nasal‐bone length at 16–24 weeks' gestation by the use of three‐dimensional (3D) ultrasound and to investigate the effect of deviations from the exact mid‐sagittalExpand
Prenasal thickness in trisomy‐21 fetuses at 16–24 weeks of gestation
TLDR
To construct a reference range for fetal prenasal thickness between 16 and 24 weeks of gestation and to evaluate the thickness in fetuses with trisomy 21, a total of 21 fetuses were studied. Expand
Assessment of the gap between the fetal nasal bones at 11 to 13 + 6 weeks of gestation by three‐dimensional ultrasound
To detect the presence of a gap between the fetal nasal bones at 11 to 13 + 6 weeks of gestation and to verify if this gap could lead to the erroneous diagnosis of absent nasal bone.
Nasal bone assessment in prenatal screening for trisomy 21.
TLDR
The potential value of assessment of the fetal nasal bone in screening for trisomy 21 is discussed and the evidence based on radiologic, histomorphologic, and sonographic studies shows that nasal bone abnormalities are significantly more common than in euploid fetuses. Expand
Two‐ and three‐dimensional sonographic assessment of the fetal face. 1. A systematic analysis of the normal face
  • D. Rotten, J. Levaillant
  • Medicine
  • Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2004
To detail fetal facial examination in utero using ultrasound, to distinguish between requirements for routine screening and those for precise analysis of fetal facial features, and to assess the useExpand
Absent or Shortened Nasal Bone Length and the Detection of Down Syndrome in Second-Trimester Fetuses
TLDR
Nasal bone length expressed as MoM seems to be an useful ultrasound marker for Down syndrome in second-trimester fetuses with a high sensitivity and a low false-positive rate. Expand
Three‐dimensional ultrasound with maximal mode rendering: a novel technique for the diagnosis of bilateral or unilateral absence or hypoplasia of nasal bones in second‐trimester screening for Down syndrome
  • B. Benoit, R. Chaoui
  • Medicine
  • Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2005
TLDR
The aim of this study was to analyze the feasibility of assessing nasal bones spatially on prenatal ultrasound in second‐ and third‐trimester fetuses with present and absent nasal bones. Expand
The prenatal development of the human nasal and vomeral bones.
TLDR
Normal prenatal development standards for the nasal and vomeral bones are established, both formed by intramembranous ossification in the membrane covering the cartilaginous nasal capsule, based upon a combination of macroscopic and microscopic analyses on normal human fetuses from spontaneous and induced abortions. Expand
Absence of nasal bone in fetuses with trisomy 21 at 11–14 weeks of gestation: an observational study
TLDR
In screening for trisomy 21, it is estimated that inclusion of examination of the fetal profile for the presence or absence of nasal bone could increase the sensitivity to 85% and decrease the false-positive rate to about 1%. Expand
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
TLDR
An alternative approach, based on graphical techniques and simple calculations, is described, together with the relation between this analysis and the assessment of repeatability. Expand
...
1
2
...