Nasal biopsy in the early diagnosis of Wegener's (pathergic) granulomatosis

  title={Nasal biopsy in the early diagnosis of Wegener's (pathergic) granulomatosis},
  author={Osamu Matsubara and Naoki Yoshimura and Yoshinori Doi and Akira Tamura and Eugene Jerome Mark},
  journal={Virchows Archiv},
The diagnostic value of the nasal biopsy in the early diagnosis of Wegener's granulomatosis and its value in prognosis were examined in 11 patients with a clinicopathological diagnosis of the disease. The vascular lesions found included microabscess in the vascular walls in 82%, leukocytoclastic capillaritis in 73%, fibrinoid necrosis of blood vessels in 45%, leukocytoclastic endovasculitis in 27%, and palisading granuloma in vascular wall in 9% of cases. The extravascular lesions included… CONTINUE READING
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