Nasal administration of recombinant osteopontin attenuates early brain injury after subarachnoid hemorrhage.

@article{Topkoru2013NasalAO,
  title={Nasal administration of recombinant osteopontin attenuates early brain injury after subarachnoid hemorrhage.},
  author={Basak caner Topkoru and Orhan Altay and Kamil Duris and Paul R Krafft and Junhao Yan and John H Zhang},
  journal={Stroke},
  year={2013},
  volume={44 11},
  pages={3189-94}
}
BACKGROUND AND PURPOSE Neuronal apoptosis is a key pathological process in subarachnoid hemorrhage (SAH)-induced early brain injury. Given that recombinant osteopontin (rOPN), a promising neuroprotectant, cannot pass through the blood-brain barrier, we aimed to examine whether nasal administration of rOPN prevents neuronal apoptosis after experimental SAH. METHODS Male Sprague-Dawley rats (n=144) were subjected to the endovascular perforation SAH model. rOPN was administered via the nasal… CONTINUE READING
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