Nasal administration of arthritis-related T cell epitopes of heat shock protein 60 as a promising way for immunotherapy in chronic arthritis.

Abstract

Adjuvant Arthritis (AA) can be induced in Lewis rats by immunisation with mycobacterial antigens. The disease can be passively transferred with T cell clone A2b, which recognises the 180-188 amino acid sequence in mycobacterial heat shock protein 60 (hsp60) and which crossreacts with crude cartilage proteoglycans. We succeeded to induce peripheral tolerance… (More)

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@article{Prakken1998NasalAO, title={Nasal administration of arthritis-related T cell epitopes of heat shock protein 60 as a promising way for immunotherapy in chronic arthritis.}, author={Berent Prakken and Marca HM Wauben and Pascal van Kooten and Stephen Mark Anderton and Ruurd van der Zee and Wietse Kuis and Wijntje J van Eden}, journal={Biotherapy}, year={1998}, volume={10 3}, pages={205-11} }