Nasal absorption and biodistribution of plasmid DNA: an alternative route of DNA vaccine delivery.

@article{Oh2001NasalAA,
  title={Nasal absorption and biodistribution of plasmid DNA: an alternative route of DNA vaccine delivery.},
  author={Y K Oh and Jungsuh P. Kim and Tae Sun Hwang and Jung Jae Ko and Jung Mogg Kim and Jeong Sun Yang and Chang Keun Kim},
  journal={Vaccine},
  year={2001},
  volume={19 31},
  pages={4519-25}
}
Nasal administration is emerging as a new route of DNA vaccine delivery. We aimed to study the extent of absorption and biodistribution of intranasally administered plasmid DNA. After intranasal administration, the level of plasmid DNA in the serum peaked at 1.5 h. The ratio of the area under the concentration (AUC) after intranasal administration of DNA over the AUC after intravenous administration was 0.14. At 15 min post inoculation, the highest organ distribution was observed in the liver… CONTINUE READING