Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin

@inproceedings{Mulcahy2012NasalCB,
  title={Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin},
  author={Michelle E Mulcahy and Joan A Geoghegan and Ian R Monk and Kate M. O'Keeffe and Evelyn J. Walsh and T. J. Foster and Rachel M McLoughlin},
  booktitle={PLoS pathogens},
  year={2012}
}
Staphylococcus aureus asymptomatically colonises the anterior nares, but the host and bacterial factors that facilitate colonisation remain incompletely understood. The S. aureus surface protein ClfB has been shown to mediate adherence to squamous epithelial cells in vitro and to promote nasal colonisation in both mice and humans. Here, we demonstrate that the squamous epithelial cell envelope protein loricrin represents the major target ligand for ClfB during S. aureus nasal colonisation. In… CONTINUE READING
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