Narrowband ultraviolet B irradiation increases the serum level of vitamin D3 in patients with neurofibromatosis 1

@article{Nakayama2013NarrowbandUB,
  title={Narrowband ultraviolet B irradiation increases the serum level of vitamin D3 in patients with neurofibromatosis 1},
  author={J. Nakayama and S. Imafuku and T. Mori and C. Sato},
  journal={The Journal of Dermatology},
  year={2013},
  volume={40}
}
The serum vitamin D3 levels in patients with neurofibromatosis 1 has been reported to be significantly lower than that in control subjects, and the level of vitamin D3 reversely correlates with the severity of neurofibroma formation. We found that narrowband ultraviolet B (NB‐UVB) irradiation increased the serum level of 1,25(OH)2 vitamin D3 in patients with neurofibromatosis 1. The difference in the 1,25(OH)2 vitamin D3 levels between patients who had received irradiation for more than 18… Expand
2 Citations
Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design
TLDR
An exhaustive and detailed analysis of the most relevant preclinical and clinical studies aimed at analyzing the correlation between vitamin D deficiency and NF1 lesion progression, thus providing important insights into disease pathogenesis and new opportunities for targeted therapy. Expand
Neurofibromatosis Type 1: New Developments in Genetics and Treatment.
TLDR
This review summarizes recent updates in genetics, mutation analysis assays, and treatment options targeting aberrant genetic pathways and proposes modified diagnostic criteria and an algorithm for surveillance of patients with neurofibromatosis type 1. Expand

References

SHOWING 1-10 OF 11 REFERENCES
Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1
TLDR
The occurrence of low serum vitamin D concentrations in people with NF1, especially those with many dermal neurofibromas, may provide new pathogenic insights and have important therapeutic implications. Expand
Vitamin D and the skin: an ancient friend, revisited
TLDR
It can be speculated that the investigation of biological effects of vitamin D analogues will lead to new therapeutic applications that, besides cancer prevention, may include the prevention and treatment of infectious as well as of inflammatory skin diseases. Expand
Vitamin D3 analogues improve café au lait spots in patients with von Recklinghausen's disease: experimental and clinical studies.
TLDR
It is considered that long-term application of vitamin D3 analogues is effective both for improving the pigmentation of café au lait spots and suppressing the development of neurofibromas in patients with von Recklinghausen's disease. Expand
In vitro responses of neurofibroma fibroblasts, mast cells and Schwann cells obtained from patients with neurofibromatosis 1 to 308‐nm excimer light and/or vitamin D3
TLDR
It is suggested that the different neurofibroma cell types show different responses to VD3, and a combination of excimer light irradiation and VD 3 is necessary to suppress the growth of neurof fibroma cells in vivo. Expand
Café-au-lait spots in neurofibromatosis type 1 and in healthy control individuals: hyperpigmentation of a different kind?
TLDR
It is concluded that SCF is an important cytokine in NF1 skin, but that additional (growth) factors and/or genetic mechanisms are needed to induce NF1-specific CALM hyperpigmentation. Expand
Neurofibromas in NF1: Schwann Cell Origin and Role of Tumor Environment
TLDR
Through use of a conditional (cre/lox) allele, it is shown that loss of NF1 in the Schwann cell lineage is sufficient to generate tumors and the requirement for a permissive haploinsufficient environment to allow tumorigenesis may have therapeutic implications for NF1 and other familial cancers. Expand
Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis
TLDR
Narrowband ultraviolet B is a routine treatment for psoriasis and atopic dermatitis but its effect on vitamin D balance is not well studied. Expand
The mechanism of epidermal hyperpigmentation in café‐au‐lait macules of neurofibromatosis type 1 (von Recklinghausen's disease) may be associated with dermal fibroblast‐derived stem cell factor and hepatocyte growth factor
TLDR
The mechanism of the accentuated melanization in café‐au‐lait macules (CALMs) in patients with neurofibromatosis type 1 (NF1; von Recklinghausen's disease) has not been elucidated. Expand
treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis
  • Br J Dematol
  • 2010
Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis
  • J Med Genet
  • 2006
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