# Narrow escape problem in two-shell spherical domains.

@article{Mangeat2021NarrowEP, title={Narrow escape problem in two-shell spherical domains.}, author={Matthieu Mangeat and Heiko Rieger}, journal={Physical review. E}, year={2021}, volume={104 4-1}, pages={ 044124 } }

Intracellular transport in living cells is often spatially inhomogeneous with an accelerated effective diffusion close to the cell membrane and a ballistic motion away from the centrosome due to active transport along actin filaments and microtubules, respectively. Recently it was reported that the mean first passage time (MFPT) for transport to a specific area on the cell membrane is minimal for an optimal actin cortex width. In this paper, we ask whether this optimization in a two-compartment…

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