Narrative review: evolving concepts in potassium homeostasis and hypokalemia.

  title={Narrative review: evolving concepts in potassium homeostasis and hypokalemia.},
  author={M Carol Greenlee and Charles S. Wingo and Alicia A McDonough and Jang-Hyun Youn and Bruce C. Kone},
  journal={Annals of internal medicine},
  volume={150 9},
Humans are intermittently exposed to large variations in potassium intake, which range from periods of fasting to ingestion of potassium-rich meals. These fluctuations would abruptly alter plasma potassium concentration if not for rapid mechanisms, primarily in skeletal muscle and the liver, that buffer the changes in plasma potassium concentration by means of transcellular potassium redistribution and feedback control of renal potassium excretion. However, buffers have capacity limits, and… CONTINUE READING