Narrative Review: Ketosis-Prone Type 2 Diabetes Mellitus

@article{Umpierrez2006NarrativeRK,
  title={Narrative Review: Ketosis-Prone Type 2 Diabetes Mellitus},
  author={Guillermo E. Umpierrez and Dawn D. Smiley and Abbas E. Kitabchi},
  journal={Annals of Internal Medicine},
  year={2006},
  volume={144},
  pages={350-357}
}
In 1987, Winter and colleagues (1) reported a small cohort of young African-American patients who, despite presenting with severe hyperglycemia or diabetic ketoacidosis, subsequently had clinical and metabolic features of type 2 diabetes. Obesity was present in 46% of these patients, and their insulin secretion in response to mixed-meal stimulation was intermediate between that seen in nondiabetic controls and in patients with type 1 diabetes. They called this form of diabetes atypical diabetes… 
Ketosis-Prone Type 2 Diabetes
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An increasing number of ketoacidosis cases without precipitating cause have also been reported in children, adolescents, and adult subjects with type 2 diabetes, mainly in Africans and African Americans.
Ketosis-Prone Type 2 Diabetes in a Veteran Population
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In a retrospective study spanning from 1999 to 2011, 62 adult veterans with new onset of diabetes presenting to the VA Greater Los Angeles Healthcare System (VAGLA) with diabetic ketoacidosis (DKA) were identified.
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Improvement in beta-cell function and insulin sensitivity by aggressive diabetic management could allow discontinuation of insulin therapy within a few month of therapy.
Diabetic ketoacidosis in Peruvian patients with type 2 diabetes mellitus.
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TLDR
In countries with a low incidence of type 1 diabetes, DKA is frequently reported in patients with type 2 diabetes, and in this study, 42% of patients had new-onset disease.
Male predominance in ketosis ‐ prone diabetes mellitus ( Review )
TLDR
The present review focuses on the role of gender hormones and other potential precipitating factors in explaining the male predominance in KPDM patients.
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TLDR
Investigation of incidence and characteristics of patients with diabetic ketosis (DK) and diabetic ketoacidosis (DKA) in Caucasian adults with type 2 diabetes mellitus (T2DM) showed that DK and DKA are not uncommon in Caucasian Adults and the majority of episodes were contributed to T2DM.
Male predominance in ketosis-prone diabetes mellitus.
TLDR
The present review focuses on the role of gender hormones and other potential precipitating factors in explaining the male predominance in KPDM patients.
Update on diagnosis, pathogenesis and management of ketosis-prone Type 2 diabetes mellitus.
TLDR
The literature on ketosis-prone Type 2 diabetes (T2DM) is reviewed and the epidemiology, putative pathophysiology and approaches to management are summarized.
Evaluation and management of ketosis-prone diabetes
TLDR
The Aß classification scheme is reviewed which accurately delineates subgroups of KPD, and the relevance of defining these subgroups for clinical outcomes and long-term insulin dependence is addressed.
Diagnosis and Management of Diabetic Ketoacidosis in Adults
TLDR
The approach to accurate diagnosis and timely management of DKA is reviewed, which focuses on treating the precipitating factors and correcting dehydration, hyperglycemia, ketosis, and electrolyte abnormalities.
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TLDR
In this population, there are atypical forms of young adult-onset ketosis-prone diabetes initially diagnosed as type 1 diabetes, differing from type 1 Diabetes in the absence of beta-cell autoimmunity, persistent beta- cell function capacity, fluctuating insulin requirements and ketotic episodes, as well as clinical features of type 2 diabetes.
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