Narp regulates long-term aversive effects of morphine withdrawal.

  title={Narp regulates long-term aversive effects of morphine withdrawal.},
  author={Irving Michael Reti and Hans S. Crombag and Kogo Takamiya and Jeffrey M. Sutton and Ning Guo and Megan L Dinenna and Richard L. Huganir and Peter C. Holland and Jay M Baraban},
  journal={Behavioral neuroscience},
  volume={122 4},
Although long-lasting effects of drug withdrawal are thought to play a key role in motivating continued drug use, the mechanisms mediating this type of drug-induced plasticity are unclear. Because Narp is an immediate early gene product that is secreted at synaptic sites and binds to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, it has been implicated in mediating enduring forms of synaptic plasticity. In previous studies, the authors found that Narp is selectively… CONTINUE READING

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