Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction.

@article{Sachdeva2014NaringinAM,
  title={Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction.},
  author={Anand Kamal Sachdeva and Anurag Kuhad and Kanwaljit Chopra},
  journal={Pharmacology, biochemistry, and behavior},
  year={2014},
  volume={127},
  pages={101-10}
}
RATIONALE Mitochondrial dysfunction has been well documented in age related disorders like Alzheimer's disease. Alterations in mitochondrial membrane potential lead to neuronal death by excessive generation of free radicals, inflammatory cytokines, and excitotoxins. Intracerebroventricular (ICV) streptozotocin (STZ) induced-cognitive impairment has been widely used as an experimental model of Alzheimer's disease. Naringin is a potent antioxidant, which can cross the blood brain barrier… CONTINUE READING
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