Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells.

@article{Jin2011NaringeninUT,
  title={Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells.},
  author={Cheng-yun Jin and Cheol Park and Hye Jin Hwang and Gi-young Kim and Byung Tae Choi and W. -G. Kim and Young Hyun Choi},
  journal={Molecular nutrition & food research},
  year={2011},
  volume={55 2},
  pages={300-9}
}
SCOPE While TRAIL is relatively non-toxic to normal cells, it can selectively induce apoptosis in many types of transformed cells. Nevertheless, some non-small cell lung cancer (NSCLC) cells are particularly resistant to the effects of TRAIL. Here, we report that in combination with naringenin exposure to TRAIL induced apoptosis in TRAIL-resistant NSCLC A549 cells with no detectable inhibitory effects on cell proliferation of normal lung fibroblast cells. METHODS AND RESULTS Cytotoxicity was… CONTINUE READING

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