Naringenin protects HaCaT human keratinocytes against UVB-induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome.

@article{Elmahdy2008NaringeninPH,
  title={Naringenin protects HaCaT human keratinocytes against UVB-induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome.},
  author={Mohamed El-mahdy and Qianzheng Zhu and Qi-En Wang and Gulzar Ahmad Wani and Srinivas Patnaik and Qun Zhao and El-Shaimaa A Arafa and Bassant M. Barakat and Safita N Mir and Altaf A. Wani},
  journal={Photochemistry and photobiology},
  year={2008},
  volume={84 2},
  pages={
          307-16
        }
}
Many naturally occurring agents are believed to protect against UV-induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB-induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53-mutant human keratinocyte HaCaT cells. The colony-forming assay shows that treatment with NG significantly increases long-term cell survival after UVB irradiation. NG treatment also… CONTINUE READING
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