Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression

  title={Naringenin promotes microglial M2 polarization and A$\beta$ degradation enzyme expression},
  author={Zhiyou Yang and Tomoharu Kuboyama and Chihiro Tohda},
  journal={Phytotherapy Research},
  pages={1114 - 1121}
Two kinds of microglia are known, classical M1 and alternative M2 phenotypes. Amyloid β (Aβ), a critical cause of Alzheimer's disease (AD), promotes M1 microglial polarization, leading to neuroinflammation and neuronal death. M2 microglia play important roles in anti‐inflammatory effects, Aβ clearance, and memory recovery in AD. Therefore, increasing of M2 microglia is expected to recover from AD. We previously found that naringenin, a blood–brain barrier penetrating compound, decreased A… 
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  • Biology
    Cellular and Molecular Neurobiology
  • 2014
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