Naringenin and 17β‐estradiol coadministration prevents hormone‐induced human cancer cell growth

@article{Bulzomi2010NaringeninA1,
  title={Naringenin and 17$\beta$‐estradiol coadministration prevents hormone‐induced human cancer cell growth},
  author={Pamela Bulzomi and Alessandro Bolli and Paola Galluzzo and Stefano Leone and Filippo Acconcia and Maria Marino},
  journal={IUBMB Life},
  year={2010},
  volume={62}
}
Flavonoids have been described as health‐promoting, disease‐preventing dietary components. In vivo and in vitro experiments also support a protective effect of flavonoids to reduce the incidence of certain hormone‐responsive cancers. In particular, our previous results indicate that the flavanone naringenin (Nar), decoupling estrogen receptor α (ERα) action mechanisms, drives cancer cells to apoptosis. Because these studies were conducted in the absence of the endogenous hormone 17β‐estradiol… 

The naringenin‐induced proapoptotic effect in breast cancer cell lines holds out against a high bisphenol a background

As a whole, Nar maintains its proapoptotic effects even in the presence of the food contaminant BPA, thus, enlarging the chemopreventive potential of this flavanone.

Naringenin modulates skeletal muscle differentiation via estrogen receptor α and β signal pathway regulation

Data reported here strongly sustain that although Nar action mechanisms include the impairment of ERα signals which drive muscle cells to differentiation, the effects triggered by Nar in the presence of ERβ could balance this negative effect avoiding the toxic effects produced by oxidative stress.

Xenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels

Data demonstrate that ERα intracellular concentration is an important target through which EDs hamper the hormonal milieu of E2 target cells driving cells to different outcomes or mimicking E2 even in the absence of the hormone.

Beyond the Antioxidant Activity of Dietary Polyphenols in Cancer: the Modulation of Estrogen Receptors (ERs) Signaling

The role and effects of food-contained polyphenols in hormone-related cancers will be reviewed, mainly focusing on the differentpolyphenols’ mechanisms of action with particular attention on their estrogen receptor-based effects, and on the consequences of such processes on tumor progression and development.

Xenoestrogen regulation of ERα/ERβ balance in hormone-associated cancers

Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer.

Various flavones, flavanones, Flavonols, isoflavones, anthocyanins, and chalcones derived from fruits, vegetables, legumes, spices, and nuts that can suppress the proinflammatory cell signaling pathways and thus can prevent and even treat the cancer.

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