Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation

@article{Harmon2004NaringeninIG,
  title={Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation},
  author={Anne W. Harmon and Yashomati M. Patel},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={85},
  pages={103-110}
}
  • A. W. Harmon, Y. Patel
  • Published 1 May 2004
  • Biology, Medicine, Chemistry
  • Breast Cancer Research and Treatment
Certain flavonoids inhibit glucose uptake in cultured cells. In this report, we show that the grapefruit flavanone naringenin inhibited insulin-stimulated glucose uptake in proliferating and growth-arrested MCF-7 breast cancer cells. Our findings indicate that naringenin inhibits the activity of phosphoinositide 3-kinase (PI3K), a key regulator of insulin-induced GLUT4 translocation, as shown by impaired phosphorylation of the downstream signaling molecule Akt. Naringenin also inhibited the… 
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