Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation

@article{Harmon2004NaringeninIG,
  title={Naringenin Inhibits Glucose Uptake in MCF-7 Breast Cancer Cells: A Mechanism for Impaired Cellular Proliferation},
  author={A. Harmon and Y. Patel},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={85},
  pages={103-110}
}
  • A. Harmon, Y. Patel
  • Published 2004
  • Medicine, Biology
  • Breast Cancer Research and Treatment
  • Certain flavonoids inhibit glucose uptake in cultured cells. In this report, we show that the grapefruit flavanone naringenin inhibited insulin-stimulated glucose uptake in proliferating and growth-arrested MCF-7 breast cancer cells. Our findings indicate that naringenin inhibits the activity of phosphoinositide 3-kinase (PI3K), a key regulator of insulin-induced GLUT4 translocation, as shown by impaired phosphorylation of the downstream signaling molecule Akt. Naringenin also inhibited the… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 42 REFERENCES
    Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*
    • 3,038
    • PDF
    Mechanism of activation of protein kinase B by insulin and IGF‐1.
    • 2,826
    Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin (*)
    • 382
    • PDF
    Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes.
    • 69