Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis

  title={Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis},
  author={Donald R Thompson},
  journal={American Journal of Gastroenterology},
  • D. R. Thompson
  • Published 1 April 2001
  • Medicine
  • American Journal of Gastroenterology
OBJECTIVE:Traditional teaching dictates that morphine induces “spasm” in the sphincter of Oddi (SO) and should not be used in acute pancreatitis and that meperidine is the analgesic of choice because it does not elevate SO pressures. A literature search and review was performed to evaluate this teaching examining the effect of narcotic analgesic's effects on SO.METHODS:A Medline search was performed using keywords and phrases. The manufacturers of meperidine were contacted and their reports and… 

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