Narcotic abstinence in dependent rats: EEG and behavioral correlates

  title={Narcotic abstinence in dependent rats: EEG and behavioral correlates},
  author={G. Young and G. F. Steinfels and N. Khazan},
  journal={Pharmacology Biochemistry and Behavior},
  • G. Young, G. F. Steinfels, N. Khazan
  • Published 1980
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • The purpose of the study was to assess and compare EEG and behavioral correlates of abstinence from morphine, methadone, LAAM, NLAAM, and DNLAAM in dependent rats. Rats were initially trained to lever press for self-injections on a FR-20 schedule of reinforcement. Following substitution of saline for each of the narcotic agonists. REM sleep was significantly suppressed during morphine, methadone, and NLAAM abstinence, but not during LAAM and DNLAAM abstinence. Significant increases in lever… CONTINUE READING
    9 Citations
    Effects of narcotic abstinence on schedule-controlled behavior in dependent rats
    • 10
    Morphine Effects on the Spontaneous Electroencephalogram in Polydrug Abusers: Correlations with Subjective Self-Reports
    • 20
    • PDF
    Opioid self-administration in rats: Pharmacodynamics and pharmacokinetics
    • 6
    Differential effects of prostaglandin synthetase inhibitors on EEG in rat.
    • 24


    Electroencephalographic, electromyographic and behavioral correlates during a cycle of selfmaintained morphine addiction in the rat.
    • 106
    Decline in the mean integrated electroencephalogram voltage during morphine abstinence in the rat.
    • 30
    Protracted rebound in rapid movement sleep time and electroencephalogram voltage output in morphine-dependent rats upon withdrawal.
    • 25
    Actions and addiction liabilities of alpha-acetyl-methadols in man.
    • 97
    Chapter 6 – Long-term Intravenous Infusion
    • 222