Narcolepsy without cataplexy: 2 subtypes based on CSF hypocretin-1/orexin-A findings.

  title={Narcolepsy without cataplexy: 2 subtypes based on CSF hypocretin-1/orexin-A findings.},
  author={Yasunori Oka and Yuichi Inoue and Takashi Kanbayashi and Kenji Kuroda and Masayuki Miyamoto and Tomoyuki Miyamoto and Akio Ikeda and Tetsuo Shimizu and Yasuo Hishikawa and Hiroshi Shibasaki},
  volume={29 11},
STUDY OBJECTIVES Cerebrospinal fluid (CSF) hypocretin-1 levels and their relationship with the clinical characteristics of narcolepsy without cataplexy have not been well elucidated. Our aim was to examine whether clinical characteristics vary with CSF hypocretin-1 levels among narcoleptic patients without cataplexy. DESIGN Clinical features, variables on the multiple sleep latency test, and results of HLA typing were correlated with CSF hypocretin-1 levels. SETTING University-based sleep… CONTINUE READING
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HLA DQB1*0602 status is related to CSF hyrpcretin-1 level in narcoleptic patients without cataplexy

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