Narcolepsy confirmed as autoimmune disease

@article{Yong2013NarcolepsyCA,
  title={Narcolepsy confirmed as autoimmune disease},
  author={Ed Yong},
  journal={Nature},
  year={2013}
}
  • E. Yong
  • Published 18 December 2013
  • Psychology
  • Nature
Results also partly explain why the 2009 swine flu virus, and a vaccine against it, led to spikes in the sleep disorder. 

Comparing General Health Status and the Risk of Comorbid Autoimmune Diseases Between Sleep Apnea and Narcolepsy Patients

The results indicate that both sleep disorders decrease a patient’s general health status, but narcolepsy has a greater likelihood of comorbid autoimmune diseases and psychiatric disorders.

COGNITIVE DEFICITS IN NARCOLEPTICS: POSSIBLE CAUSES, SIMILARITIES TO ADHD, AND CLASSROOM ACCOMMODATIONS

49 pages. A thesis presented to the Department of General Science and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of

References

SHOWING 1-2 OF 2 REFERENCES

CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy

Results point to a possible molecular mimicry between epitopes on hypocretin and the influenza hemagglutinin protein, and an increased frequency of circulating HCRT56–68– and H CRT87–99–reactive T cells.

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.

Findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy and indicate that complex HLA-DR and -DQ interactions contribute to the genetic predisposition to human narCOlepsy but that additional susceptibility loci are also most likely involved.