Narcolepsy confirmed as autoimmune disease

@article{Yong2013NarcolepsyCA,
  title={Narcolepsy confirmed as autoimmune disease},
  author={Ed Yong},
  journal={Nature},
  year={2013}
}
  • E. Yong
  • Published 18 December 2013
  • Psychology
  • Nature
Results also partly explain why the 2009 swine flu virus, and a vaccine against it, led to spikes in the sleep disorder. 
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Background Citations
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2 Citations

Comparing General Health Status and the Risk of Comorbid Autoimmune Diseases Between Sleep Apnea and Narcolepsy Patients

The results indicate that both sleep disorders decrease a patient’s general health status, but narcolepsy has a greater likelihood of comorbid autoimmune diseases and psychiatric disorders.

COGNITIVE DEFICITS IN NARCOLEPTICS: POSSIBLE CAUSES, SIMILARITIES TO ADHD, AND CLASSROOM ACCOMMODATIONS

49 pages. A thesis presented to the Department of General Science and the Clark Honors College of the University of Oregon in partial fulfillment of the requirements for degree of Bachelor of…

References

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CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy

Results point to a possible molecular mimicry between epitopes on hypocretin and the influenza hemagglutinin protein, and an increased frequency of circulating HCRT56–68– and H CRT87–99–reactive T cells.

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.

Findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy and indicate that complex HLA-DR and -DQ interactions contribute to the genetic predisposition to human narCOlepsy but that additional susceptibility loci are also most likely involved.