Narcolepsy and the hypocretin system—where motion meets emotion

  title={Narcolepsy and the hypocretin system—where motion meets emotion},
  author={Jerome M Siegel and Lisa N Boehmer},
  journal={Nature Clinical Practice Neurology},
Narcolepsy is a neurological disorder that is characterized by excessive daytime sleepiness and cataplexy—a loss of muscle tone generally triggered by certain strong emotions with sudden onset. The underlying cause of most cases of human narcolepsy is a loss of neurons that produce hypocretin (Hcrt, also known as orexin). These cells normally serve to drive and synchronize the activity of monoaminergic and cholinergic cells. Sleepiness results from the reduced activity of monoaminergic… CONTINUE READING


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