Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity.

@article{Tafti2016NarcolepsyAssociatedHC,
  title={Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity.},
  author={M. Tafti and G. Lammers and Y. Dauvilliers and S. Overeem and G. Mayer and J. Nowak and Corinne Pfister and V. Dubois and Jean-François Eliaou and Hans-Peter Eberhard and R. Liblau and A. Wierzbicka and P. Geisler and C. Bassetti and J. Mathis and M. Lecendreux and R. Khatami and R. Heinzer and J. Haba-Rubio and E. Feketeov{\'a} and C. Baumann and Z. Kutalik and J. Tiercy},
  journal={Sleep},
  year={2016},
  volume={39 3},
  pages={
          581-7
        }
}
STUDY OBJECTIVES Narcolepsy with cataplexy is tightly associated with the HLA class II allele DQB1*06:02. Evidence indicates a complex contribution of HLA class II genes to narcolepsy susceptibility with a recent independent association with HLA-DPB1. The cause of narcolepsy is supposed be an autoimmune attack against hypocretin-producing neurons. Despite the strong association with HLA class II, there is no evidence for CD4+ T-cell-mediated mechanism in narcolepsy. Since neurons express class… Expand
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