Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate.

@article{Huang2009NarcolepsyAO,
  title={Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate.},
  author={Yu-Shu Huang and Christian Guilleminault},
  journal={Pediatric neurology},
  year={2009},
  volume={41 1},
  pages={
          9-16
        }
}
This study was performed to evaluate the actions of baclofen and sodium oxybate, two medications with gamma-aminobutyric acid type B (GABA(B)) receptor agonist properties, on symptoms of narcolepsy in drug-naïve teenagers. Twenty-six narcoleptic teenagers with recent onset of narcolepsy-cataplexy syndrome who were human leukocyte antigen DQB1 0602 positive were matched for age and sex and received either baclofen or sodium oxybate. If deemed necessary to combat excessive daytime sleepiness, the… CONTINUE READING
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