Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states.

@article{Todd1990NaproxenAR,
  title={Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states.},
  author={Patricia A. Todd and Stephen P. Clissold},
  journal={Drugs},
  year={1990},
  volume={40 1},
  pages={
          91-137
        }
}
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) advocated for use in painful and inflammatory rheumatic and certain nonrheumatic conditions. It may be administered orally or rectally using a convenient once or twice daily regimen. Dosage adjustments are not usually required in the elderly or those with mild renal or hepatic impairment although it is probably prudent to start treatment at a low dosage and titrate upwards in such groups of patients. Numerous clinical trials have… 
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References

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TLDR
A patient with fulminant cutaneous necrotizing venulitis temporally associated with the administration of naproxen is described, a 43-year-old diabetic woman with chronic active hepatitis who was hospitalised for a lymph node biopsy and received 250 mg of Naproxen twice daily for chest wall pain that was unresponsive to acetaminophen and codeine.
A comparative study of isoxicam and naproxen in rheumatoid arthritis.
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    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
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TLDR
In this study isoxicam 200 mg taken once daily was similar in efficacy to and was associated with a similar incidence of adverse reactions as naproxen 250 mg taken 3 times daily, which were effective in the treatment of rheumatoid arthritis and were well tolerated.
Controlled-release naproxen compared with isoxicam in patients with osteoarthritis.
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TLDR
Naproxen CR and isoxicam proved equally effective and well-tolerated for the treatment of osteoarthritis in this study.
Antrafenine, naproxen and placebo in osteoarthritis: a comparative study.
TLDR
Antrafenine, at either dose, was effective in relieving pain associated with osteoarthritis; the efficacy was comparable to naproxen and any noted side-effects were mild.
Nabumetone, a new non-steroidal anti-inflammatory drug: a comparison with naproxen.
TLDR
Nabumetone may have a useful role in the management of patients with poor tolerance of other anti-inflammatory drugs, as patients known to be intolerant to naproxen were excluded from the trial.
Etodolac versus naproxen in rheumatoid arthritis: a double-blind crossover study.
TLDR
After 6-weeks' therapy, patients receiving etodolac showed a statistically significant improvement in their global self-evaluation and erythrocyte sedimentation rate compared to naproxen, and the results indicated that, overall, both drugs were equally effective.
Efficacy and tolerance of naproxen versus pirprofen in the treatment of patients with osteoarthritis.
TLDR
A double-blind, double-dummy study design was used to compare the efficacy and tolerance of naproxen with that of pirprofen in the treatment of osteoarthritis, and both medications were shown to be well tolerated, acceptable, and effective for treating osteOarthritis.
Gastrointestinal Microbleeding Associated with the Use of Etodolac, Ibuprofen, Indomethacin, and Naproxen in Normal Males
TLDR
Etodolac at doses in excess of the mean effective dose in osteoarthritis and rheumatoid arthritis caused significantly less microbleeding in normal male volunteers during the seven‐day treatment period than the other drugs tested, and not clinically more than that occurring during baseline placebo.
Naproxen and acetylsalicylic acid in the treatment of pauciarticular and polyarticular juvenile rheumatoid arthritis. Assessment of tolerance and efficacy in a single-centre 24-week double-blind parallel study.
TLDR
The outcome of the study indicated that ASA may have a slight advantage over NAP with regard to efficacy, however, the changes in disease activity measurements were similar in the two treatment groups.
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