Naproxen oral absorption characteristics.

  title={Naproxen oral absorption characteristics.},
  author={Richard Allen Runkel and Kurt Kraft and G Boost and Hilli Sevelius and Enrico Forchielli and Rachel Hill and R E Magoun and J B Szakacs and Enrico Segre},
  journal={Chemical & pharmaceutical bulletin},
  volume={20 7},
Oral doses of 2.5 mg/kg of naproxen in beagle dogs were found to be rapidly and completely absorbed. In the dog, the sodium and calcium salts of naproxen were absorbed significantly faster than the non-micronized form of naproxen, while the micronized drug could not be distinguished from either the salts or the macro from. Area responses to intravenous and oral doses of naproxen in two human subjects showed that oral doses of 200 and 250 mg were apparently one hundred percent absorbed. In a… CONTINUE READING