Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial.

Abstract

We performed a prospective, randomized, open-label equivalence study comparing the use of naproxen to aspirin in 33 patients with rheumatic fever. The mean time until resolution of arthritis was 2.9+/-2.9 days in both groups. Liver enzyme elevations were more frequent in the aspirin group (P=.002). We conclude that naproxen is as effective, is easier to use, and is safer than aspirin in the treatment of the arthritis of rheumatic fever.

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@article{Hashkes2003NaproxenAA, title={Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial.}, author={Philip J. Hashkes and Tsivia Tauber and E. Somekh and Riva Brik and Judith Barash and Masza Mukamel and Liora Harel and Abraham Lorber and Matityahu Berkovitch and Yosef Uziel}, journal={The Journal of pediatrics}, year={2003}, volume={143 3}, pages={399-401} }