• Corpus ID: 10041491

Naphthoquinone : Bioactivity and Green Synthesis

@inproceedings{RamosPeralta2015NaphthoquinoneB,
  title={Naphthoquinone : Bioactivity and Green Synthesis},
  author={L. Ramos-Peralta and Lluvia Itzel L{\'o}pez-L{\'o}pez and Sonia Yesenia Silva-Belmares and Alejandro Zugasti-Cruz and Ra{\'u}l Rodr{\'i}guez‐Herrera and Crist{\'o}bal N. Aguilar-Gonz{\'a}lez},
  year={2015}
}
Naphthoquinones are secondary metabolites isolated from different plant, bacterial, fungal and animal sources; traditionally these compounds are used for their dyeing properties, however, actually different biological activities of these compounds have been reported. In most cases, these activities are due to its ability to accept one or two electrons to form the corresponding anion or di-anion radical, which can be modulated synthetically by modifying the substituents attached to the 1,4… 
microbiology5.org
3 Citations

Figures and Tables from this paper

3 Citations

Citation Type

Citation Type

Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity
TLDR
Solid dispersions prepared between IVS320 and polymers hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP) were developed using physical mixture, kneading, and rotary evaporation methods, and in vitro antiparasitic activity in Trypanosoma cruzi Y strains was evaluated.
Antibacterial metabolites from Bipolaris specifera, an endophytic fungus from the endemic medicinal plant, Zingiber nimmonii (J. Graham) Dalzell
TLDR
The study envisages the possible drug discovery using endophytes from traditional and endemic medicinal species and identified seven antibacterial compounds, mainly volatile esters of fatty acids, phenolics and adipic acid found rare in nature.
Quantitative Structure Activity Relationship (QSAR) Study of 1,4 – Naphthoquinone Derivatives as Anticancer Agents

References

SHOWING 1-10 OF 79 REFERENCES
The chemical biology of naphthoquinones and its environmental implications.
TLDR
The chemistry, biochemistry, and cellular effects of 1,2- and 1,4-naphthoquinones and their derivatives are described, which are of particular interest because of their prevalence as natural products and as environmental chemicals.
Synthesis and antifungal activity of terpenyl-1,4-naphthoquinone and 1,4-anthracenedione derivatives.
Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives.
SYNTHESIS OF SOME 1,4-NAPHTHOQUINONES AND REACTIONS RELATING TO THEIR USE IN THE STUDY OF BACTERIAL GROWTH INHIBITION,
Abstract : A series of 107 1,4-naphthoquinones and related products has been synthesized to study their mode of action in bacterial growth inhibition. The in vitro reactions of a number of these with…
Synthesis, molecular docking and antibacterial evaluation of new 1,4-naphthoquinone derivatives contains carbazole-6,11-dione moiety
TLDR
This set of compounds has been evaluated for in vitro antibacterial studies against different Gram-positive and Gram-negative bacteria, and most of the synthesized compounds exhibited good antibacterial activity and the minimum inhibitory concentrations (MICs) are compared with the standard drugs used.
Antibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives.
Evaluation of plumbagin and its derivative as potential modulators of redox thiol metabolism of Leishmania parasite
TLDR
The kinetics of the inhibitory mechanism of plumbagin and its derivative, 2-methoxy 1, 4-naphthoquinone, apart from acting as inhibitor, these compounds also act as subversive substrates and subvert the physiological function of enzyme by converting it from an antioxidant to a prooxidant.
In vitro antifungal activity of naphthoquinone derivatives.
TLDR
In vitro antifungal activities of naphtoquinone-derivatives, which are constituents of Shikon, roots of Lithospermum erythrorhizon, were investigated against several fungal pathogens and shikon was found to have a stronger than fluconazole against yeast-like fungi.
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
TLDR
Genetic validation that IDO is the critical in vivo target is demonstrated using IDO-null mice and a new class of naphthoquinone-based IDO inhibitors exemplified by the natural product menadione is defined, shown in mouse tumor models to have similar antitumor activity to previously characterized IDO abusers.
Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents.
...
1
2
3
4
5
...