Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex.

@article{Nadai2011NaphthaleneDS,
  title={Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex.},
  author={Matteo Nadai and F. A. M. D{\'o}ria and Marco di Antonio and Giovanna Sattin and Luca Germani and Claudia Percivalle and Manlio Palumbo and Sara N Richter and Mauro Freccero},
  journal={Biochimie},
  year={2011},
  volume={93 8},
  pages={1328-40}
}
Selective recognition and alkylation of G-quadruplex oligonucleotides has been achieved by substituted naphathalene diimides (NDIs) conjugated to engineered phenol moieties by alkyl-amido spacers with tunable length and conformational mobility. FRET-melting assays, circular dichroism titrations and gel electrophoresis analysis have been carried out to evaluate both reversible stabilization and alkylation of the G-quadruplex. The NDIs conjugated to a quinone methide precursor (NDI-QMP) and a… CONTINUE READING

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